Pharmacologists have worked for years to distill benzodiazepines' desirable effects, says neuroscientist Richard Olsen of the University of California, Los Angeles. Mice with unresponsive a2 receptors, however, were equally anxious with or without Valium-suggesting that the a2 receptor is where the drug works to reduce anxiety, they report in the 6 October issue of Science. Given a dose of the drug, they were more likely to venture into new wings of a maze and well-lit places-a standard lab measure of lessened anxiety-than were undrugged mice. When the researchers interfered with the a3 receptor's ability to pick up Valium, the mice were completely normal.
The two candidates, a2 and a3 receptors, show up in the parts of the brain that respond to fear. They engineered two mice strains with dysfunctional receptors. This is due to the anxiolytic, anticonvulsant, muscle relaxing and sedative properties that these medicines provide. Next the researchers wanted to figure out which receptor sends the drugs' soothing signals. What is Valium Used for Benzodiazepines are renowned for their long duration time and ability to treat a multitude of conditions. Last year, a team led by Uwe Rudolph of the University of Zürich in Switzerland reported that, in mice, only one of those receptor types is responsible for benzodiazepines' side effect of sleepiness. The drugs boost the efficiency of a chemical messenger called GABA, which flips the brain's main "off switch." Four types of GABA receptors-the switches on the outside of neurons-are sensitive to benzodiazepines. Our Valium Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
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The chemical compounds known as benzodiazepines, such as Valium, calm the brain by discouraging neurons from firing. Be sure you know how to take diazepam and what other drugs you should avoid taking with it. rectal gel/jelly Warning Oral route (Tablet Solution) Risks From Concomitant use with Opioids Abuse, Misuse, and Addiction and Dependence and Withdrawal Reactions Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Brand and Other Names:Valium, Diastat AcuDial, more.Valtoco. Now researchers have identified a receptor in the brain that's responsible for just the drug's antianxiety powers-opening up the possibility that a drug targeted to that receptor could ease anxiety without causing drowsiness, clumsiness, and memory loss. Medscape - Antianxiety, antiseizure-specific dosing for Valium. Valium and related drugs are among the world's most popular treatments for anxiety, despite numerous side effects. Diazepam (Valium - Roche) is a newer drug chemically related to chlordiazepoxide and its advertised indications are similar to those suggested for Librium.
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